The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.ĭamage to the heart from high doses of ionizing radiation has been detected in radiotherapy patients. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: This work was supported by a project of the Federal Office of Radiation Protection (contract 3611S30022) and by the EU project ProCardio (contract number 295823).
Received: NovemAccepted: ApPublished: May 14, 2014Ĭopyright: © 2014 Simonetto et al. PLoS ONE 9(5):Įditor: Suminori Akiba, Kagoshima University Graduate School of Medical and Dental Sciences, Japan With respect to internal radiation exposure no association to risk could be established.Ĭitation: Simonetto C, Azizova TV, Grigoryeva ES, Kaiser JC, Schöllnberger H, Eidemüller M (2014) Ischemic Heart Disease in Workers at Mayak PA: Latency of Incidence Risk after Radiation Exposure. For mortality, significant risk was found in males with an excess relative risk per dose of 0.09 (95% CI: 0.02 0.16) while risk was insignificant for females. We extend the analysis of the significant incidence risk and observe that main detrimental effects of external radiation exposure occur after more than about 30 years. 2012, the updated dosimetry system MWDS-2008 has been applied and methods of analysis have been revised. Compared to a previous study by Azizova et al. While most of the workers have been exposed to external gamma radiation, a large proportion has additionally been exposed to internal radiation from inhaled plutonium. It is exceptional because it comprises information on several other risk factors. This cohort constitutes one of the most important sources for the assessment of radiation risk. We present an updated analysis of incidence and mortality from atherosclerotic induced ischemic heart diseases in the cohort of workers at the Mayak Production Association (PA).
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